Intracellular crowding of macromolecules defines the mode and sequence of substrate uptake by E. coli and constrains its metabolic activity and growth Supporting Information, Part 1: Modeling framework
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چکیده
Q.K. Beg, A. Vázquez, J. Ernst, M.A. de Menezes, Z. Bar-Joseph, A.-L. Barabási and Z.N. Oltvai Department of Pathology, University of Pittsburgh, Pittsburgh, PA, 15261, USA The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA Machine Learning Department, Carnegie-Mellon University, Pittsburgh, PA, 15217, USA Instituto de Física, Universidade Federal Fluminense, Rio de Janeiro, 24210, Brazil. Department of Physics and Center for Complex Networks Research, University of Notre Dame, Notre Dame, IN 46556, USA
منابع مشابه
Intracellular crowding of macromolecules defines the mode and sequence of substrate uptake by E. coli and constrains its metabolic activity and growth Supporting Information, Part 2: Experimental protocols and microarray analyses
Q.K. Beg, A. Vázquez, J. Ernst, M.A. de Menezes, Z. Bar-Joseph, A.-L. Barabási and Z.N. Oltvai Department of Pathology, University of Pittsburgh, Pittsburgh, PA, 15261, USA The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA Machine Learning Department, Carnegie-Mellon University, Pittsburgh, PA, 15217, USA Instituto de Física, Universidade Federal Flum...
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The influence of the high intracellular concentration of macromolecules on cell physiology is increasingly appreciated, but its impact on system-level cellular functions remains poorly quantified. To assess its potential effect, here we develop a flux balance model of Escherichia coli cell metabolism that takes into account a systems-level constraint for the concentration of enzymes catalyzing ...
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تاریخ انتشار 2007